|
KMID : 1034720200120020067
|
|
Journal of Neurosonology and Neuroimaging
2020 Volume.12 No. 2 p.67 ~ p.72
|
|
|
The Relationship between Changes in Systemic Blood Viscosity and Transcranial Doppler Pulsatility in Lacunar Stroke
|
|
Kim Tae-Min
Oh Jin-Young
Han Ji-Eun
Park Joong-Hyun
Baik Jong-Sam
Kim Jeong-Yeon
Park Jae-Hyeon
Han Sang-Won
Kim Eung-Gyu
|
|
|
Abstract
|
|
|
Background: We hypothesized that changes in blood viscosity (BV) would influence cerebral vessel viscosity, which is related to the transcranial Doppler (TCD) pulsatility index (PI). Using serial BV and TCD examinations, we sought to evaluate the relationship between changes in BV and TCD PI in lacunar stroke patients.
Methods: Patients (aged ≥50 years) who developed lacunar stroke within 7 days of symptom onset were enrolled. Laboratory tests and TCD examinations were conducted at admission and 180 (±30) days after the onset of stroke. Patients were categorized into the decreased BV and increased BV groups. Decreased BV suggested that the BV value in the baseline study minus the 180-day study was positive, and vice-versa.
Results: A total of 128 patients who had experienced classic lacunar syndromes were enrolled and 67 (52%) were included in the final analysis. At the end of the 180-day study, changes in systolic BV (SBV) were not associated with PI changes. Regarding diastolic BV (DBV), hematocrit (Hct) adjusted partial correlation analysis showed no significant relationship between changes in DBV and PI (r=0.25, p=0.068). The correlation analysis showed that changes in hemoglobin and Hct were positively associated with SBV and DBV changes (r>0.488, p<0.0001 and r>0.461, p<0.0001), confirming that Hct was the major determinant factor of BV.
Conclusion: This study did not show a relationship between changes in BV and cerebral arterial pulsatility in patients with lacunar stroke. The changes in BV were positively associated with changes in Hct.
|
|
|
KEYWORD
|
|
|
Blood viscosity, Stroke, Ultrasonography
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|